ASEE PEER - Reimagining Protein Engineering Education: Active Learning with Computational Workshops
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Reimagining Protein Engineering Education: Active Learning with Computational Workshops

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Conference

2025 ASEE PSW Conference

Location

California Polytechnic University, California

Publication Date

April 10, 2025

Start Date

April 10, 2025

End Date

April 12, 2025

DOI

10.18260/1-2--55188

Permanent URL

https://peer.asee.org/55188

Paper Authors

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William Charles Sobolewski University of California, Santa Cruz Orcid 16x16 orcid.org/0009-0006-3890-4808

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Abstract

This submission is for a poster presentation at the 2025 ASEE-PSW Conference under the theme Leading Tomorrow: Educating Engineers for Innovation, Collaboration, and Entrepreneurship.

The poster highlights the redesign of an upper-division Protein Engineering course at the University of California, Santa Cruz, focused on integrating hands-on computational workshops to enhance student engagement and learning outcomes. Responding to feedback from previous cohorts, the course will now include more practical training in cutting-edge tools such as Rosetta and AlphaFold, both of which were recognized with the 2024 Nobel Prize in Chemistry. The revised curriculum also workshops on molecular visualization software for scientific communication and effective utilization of open-source resources like the Protein Data Bank (PDB) for protein structure analysis and design.

These workshops are tailored for students with foundational knowledge in biochemistry, no prior experience with coding languages, and limited exposure to protein engineering methodologies. They aim to bridge the gap between theoretical lecture concepts and real-world applications in protein design. The poster will evaluate the impact of these updates, including the newly introduced workshops, following the redesigned course’s first offering. Assessment will focus on data from student engagement, polling feedback, and the elected application of workshop-taught tools by the students in their final design projects. A comparative analysis of outcomes before and after the curriculum changes will offer valuable insights into the workshops’ effectiveness in enhancing technical proficiency, fostering creativity, and promoting collaborative problem-solving.

This redesign represents an innovative, forward-looking approach to teaching protein engineering, showcasing the value of active learning and computational training in preparing students for interdisciplinary challenges in biotechnology and synthetic biology.

Sobolewski, W. C. (2025, April), Reimagining Protein Engineering Education: Active Learning with Computational Workshops Paper presented at 2025 ASEE PSW Conference, California Polytechnic University, California. 10.18260/1-2--55188

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