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amount of basic science information that can be fit into any given lecture. The instructor must hone the lecture to encompass only the most important topics, and restrict remedial material to the most relevant. Once again, a textbook written within only a few disease contexts would limit the number of occasions new diseases must be introduced, and recoup much of this cost.

Finally, teaching a class in this manner represents a significant workload. The instructor must develop a superficial knowledge of each disease that is presented. Further, the review articles take large amounts of instructor time at mid semester, when the first drafts and reviews must all be read and summarized.

V. Table of possible course topics

The following table shows a possible ordering of lecture topics, including the relevant chapters in Lodish et al.2, disease themes and relative due dates for review article sections. Breaks and exams have been omitted. Thick lines indicate general topical breaks.

Topic Chapter System / Disease Paper Introduction Membranes and cell structure 5 Asthma Protein structure & methods 3 Transplant rejection & autoimmune disease The central dogma 4 Letter Recombinant DNA and genomics 7 Diversity in immunity Genes and chromosomes 9 Immunity: antibody diversity Regulation of transcription 10 Diabetes RNA processing 11 Replication 12 Bladder infections & antibiotics Cell cycle regulation 13 DNA damage and malignancy Protein sorting and endocytosis 17 Atherosclerosis First draft Extracellular matrix 22 Inflammation Membrane transport 15 Cystic fibrosis Excitability and nerve cells 21 Duchainne-Barr syndrome Microfilaments and contraction 18 Hypertrophic cardiomyopathy Reviews Microtubules and IFs 19 Kartagener syndrome G proteins and second 20 Cholera messengers Cancer 24 Cancer Final draft

Bibliography th 1. Campbell, N.A., Reece, J.B. and Mitchell, L.G. Biology. 5 Ed. Menlo Park, CA: Benjamin/Cummings (1999). th 2. Lodish, H., Berk, A., Zipursky, S.L., Matsudaira, P., Baltimore, D. and Darnell, J. Molecular Cell Biology, 4 Ed.

Proceedings of the 2001 American Society for Engineering Education Annual Conference & Exposition Copyright  2001, American Society for Engineering Education

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Guilford, W. (2001, June), A Problem Based Approach To Teaching Cell And Molecular Biology To Engineers Paper presented at 2001 Annual Conference, Albuquerque, New Mexico. 10.18260/1-2--9676