June 23, 2013
June 23, 2013
June 26, 2013
NSF Grantees Poster Session
23.167.1 - 23.167.12
Proposed Abstract for the NSF Grantees Poster SessionAn Experiment to Introduce pH-responsive Hydrogels for Controlled Drug DeliveryMadina Yermagambetova, Stephanie Farrell and Jennifer VernengoDepartment of Chemical EngineeringRowan UniversityIn an continuing effort to introduce drug delivery-related experiments for the chemicalengineering curriculum, we are developing an experiment to introduce students to pHresponsive hydrogels. These hydrogels have been extensively investigated for controlleddrug delivery. By responding to the pH environment in the body, which changesdepending on location and metabolic state, a pH-sensitive drug dosage form is able tomodulate drug delivery patterns to meet physiologic requirements and minimize sideeffects. This paper describes an experiment used to introduce engineering students in amaterials science class to stimuli-responsive polymers for controlled release applications.Students produce a pH responsive hydrogel using a free-radical solution polymerization.The physical and mechanical properties of the hydrogel such as swelling, density, andtensile strength are tested with and without drug loading, after exposure to different pHenvironments. Finally, the drug release profiles were analyzed in different pHenvironments. At low pH (typical stomach values of 1.2-5.0) the drug did not swell anddrug was released very slowly. At neutral pH (representative of gastric emptying), thegels swelled rapidly and released drug at a controlled rate. Such a system would beuseful for the oral delivery of a drug that would be damaged by the low pH environmentof the stomach, such as insulin. In addition to learning about pH-responsive drugdelivery, students learned concepts of measurements, material properties, design ofexperiments, data analysis, and engineering design. This experiment will beimplemented in the fall 2012 semester, and the paper will present results of the project.
Farrell, S., & Vernengo, J., & Yermagambetova, M., & Schwalbenberg, P. J. (2013, June), An Experiment to Introduce pH-responsive Hydrogels for Controlled Drug Delivery: Mechanical Testing Paper presented at 2013 ASEE Annual Conference & Exposition, Atlanta, Georgia. 10.18260/1-2--19181
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