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Chemotherapy in Cancer Tumor Treatment: An Interplay of Scales, Transport, and Kinetics

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Conference

ASEE Southeast Section Conference

Location

Arlington, Virginia

Publication Date

March 12, 2023

Start Date

March 12, 2023

End Date

March 14, 2023

Conference Session

Using Research in Engineering Ed

Tagged Topic

Professional Engineering Education Papers

Page Count

7

DOI

10.18260/1-2--44991

Permanent URL

https://peer.asee.org/44991

Download Count

85

Paper Authors

biography

Pedro E. Arce Tennessee Technological University Orcid 16x16 orcid.org/0000-0002-9869-9942

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Dr. P. E. Arce is University Distinguished Faculty Fellow, Professor and Past Department Chair of Chemical Engineering at TTU, Cookeville, TN-Currently, he is a co-coordinator of the Grad Engineering Education Task Force of the TTU College of Engineering

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biography

Sahera Yasmin Abumariam Tennessee Tech University

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Sahera Abumariam is a senior at Tennessee Tech University, where she is majoring in chemical engineering with a minor in mathematics and science. Her interests are in mathematical modeling research on cancer treatments, water treatments, and cosmetic science. Her research has consisted of hyperthermia treatments, fluid mechanics understanding, and now chemotherapy in cancer tumor treatment: an Interplay of Scales, Transport, and Kinetics.

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Abstract

The understanding of how chemotherapy action works in cancer tumor treatment is a complex learning challenge. First, the domain, i.e., the tumor tissue is an intricated porous media with several scales present from molecular, microscopic, and macroscopic level that require a detailed knowledge to present a description of the chemotherapy action. Second, the motion of drugs toward the targeted site, i.e., the tumor cells is driven by convective and diffusive transport that take place at the different scales of the tumor domain. Finally, the chemotherapy occurs by the different chemical reactions taking place at the targeted site, i.e., the cancer tumor cells. Using a guided-inquired approach coupled with the Renaissance Foundry Model, this contribution focuses on aiding the students in describing the role of the different scales, modes of transport, and reaction taking place within the tumor domain. This contribution connects the various learning pieces associated with, for example, scales, selection of control domains (within these scales), formulation of the differential models based on conservation principles of species mass, selection of boundary conditions and up-scaling procedures. The overall approach illustrates a powerful Principal Object of Knowledge (POK) case to systematically introduce students to mass transfer in biotechnological applications and bring non-dimensional numbers as well as limiting cases chiefly needed to understand how chemotherapy works in cancer treatment process. The analysis is focused on isothermal mass transfer process; however, they are easily extended to other conditions in case they are needed.

Arce, P. E., & Abumariam, S. Y. (2023, March), Chemotherapy in Cancer Tumor Treatment: An Interplay of Scales, Transport, and Kinetics Paper presented at ASEE Southeast Section Conference, Arlington, Virginia. 10.18260/1-2--44991

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