June 18, 2006
June 18, 2006
June 21, 2006
Division Experimentation & Lab-Oriented Studies
11.624.1 - 11.624.11
Experiments in Drug Delivery for Undergraduate Engineering Students
Introduction Drug Delivery is a burgeoning field that represents one of the major research and development focus areas of pharmaceutical industry today, with new drug delivery system sales exceeding 54 billion dollars per year 1. Chemical Engineers play an important and expanding role in this exciting field, yet undergraduate chemical engineering students are rarely exposed to drug delivery through their coursework. To provide students with the skills directly relevant to the evolving needs of the pharmaceutical industry, this we have developed and integrated applied drug delivery coursework and experiments throughout the Rowan Engineering curriculum. To design and produce a new drug delivery system, an engineer must fully understand the drug and material properties and the processing variables that affect the release of the drug from the system. This requires a solid grasp of the fundamentals of mass transfer, reaction kinetics, thermodynamics and transport phenomena. He or she must also be skilled in characterization techniques and physical property testing of the delivery system, and practiced in the analysis of the drug release data. We have developed several classroom and laboratory modules that introduce students to multidisciplinary engineering principles through application to drug delivery systems. Each module comprises experiments for the design, preparation, characterization, and analysis of a variety of drug delivery systems. This paper describes experiments developed to investigate tablets, transdermal patch systems, drug stability and supercritical fluid applications. Experiments related to ointments and microcapsules are also being developed, and are described here. The experimental methods and engineering concepts used to analyze drug delivery systems are presented, and the role of the engineer in this field is explored. Controlled drug delivery systems attempt to deliver a drug to the body at a controlled rate for an extended period of time. Historically, drug delivery systems were developed primarily for traditional routes of administration such as oral and intravenous. Recently, however, there has been an explosion in research on delivery by so-called non-conventional routes, such as transdermal, nasal, ocular, and pulmonary administration. Drug delivery applications have expanded from traditional drugs to therapeutic peptides, vaccines, hormones, and viral vectors for gene therapy. These systems employ a variety of rate-controlling mechanisms, including matrix diffusion, membrane diffusion, biodegradation and osmosis. To design and produce a new drug delivery system, an engineer must fully understand the drug and material properties and the processing variables that affect the release of the drug from the system. This requires a solid grasp of the fundamentals of mass transfer, reaction kinetics, thermodynamics and transport phenomena. He or she must also be skilled in characterization techniques and physical property testing of the delivery system, and practiced in the analysis of the drug release data.
The engineering goals of this project are (1) to explore different types of drug delivery systems; (2) to study drug delivery designs in a quantitative manner using engineering principles; (3) to use up-to-date industrial techniques for the production, testing and analysis of drug delivery systems; and (4) to evaluate factors influencing the drug release from a delivery system.
Farrell, S., & Savelski, M., & Hesketh, R., & Slater, C. S. (2006, June), Experiments In Drug Delivery For Undergraduate Engineering Students Paper presented at 2006 Annual Conference & Exposition, Chicago, Illinois. https://peer.asee.org/245
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