June 23, 2013
June 23, 2013
June 26, 2013
Computing & Information Technology
23.636.1 - 23.636.17
Genomics, Signal Processing, Bioinformatics, and Imaging Maurice F. Aburdene Marie C. Pizzorno Alex ThompsonWe present our approach to teaching an elective course focusing on genomics, signal processing,bioinformatics, and medical imaging for biology, biochemistry, electrical engineering, and computerengineering students. The objective of the course is to learn about current issues in mathematicalbiology, computational biology, and bioinformatics, from an engineering perspective. The course isbeing offered for the first time in the Fall of 2012.Since today’s biologists are not only scientists, but also “engineers”, due to their ability to “buildsystems”, the course presents a multidisciplinary view of research and problem solving, which will beuseful with study of any topic, and not just genomic signal processing. The course content is broad andrequires a background in biology, mathematics, physics, chemistry, statistics, computer science andsignal processing. In addition, we draw on the resources of several academic departments and visitinglecturers to provide fundamental concepts from each field. The course outline is ambitious and willevolve, adapt, mutate, and crossover to other topics in the future.The format or course-plan and content for the course are described, along with suggestedimprovements in the future.The course contents include following topics: • Introduction to the Course and Objectives • Genetic Algorithms • Genomic Companies • DNA Sequencing Methods • Bioinformatics, Introduction to Matlab Bioinformatics Tool box, • DNA Data Bases and Sequence Search Tools • Basic Statistical Computations on DNA Sequences • Using Large Electronic Datasets for Observational Clinical Studies • DNA Indicator Sequences, Periodic Signals • Fourier Transforms, Discrete Fourier Transforms (DFT), Fast Fourier Transforms ( FFT) • Using Fourier Methods to Find Protein Coding Regions • Using correlation to compare DNA sequences • DNA Filter design (Digital Filtering)• Bioinformatics• Network Analysis of Complex Biological Systems• Applications• Peer Review of Term Papers/Projects The paper will present a critique of the course and suggestions for improvement.
Aburdene, M. F., & Pizzorno, M. C., & Thompson, A. P. (2013, June), Genomics, Signal Processing, and Bioinformatics Paper presented at 2013 ASEE Annual Conference & Exposition, Atlanta, Georgia. https://peer.asee.org/19650
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