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Integration of Particle Technology with Pharmaceutical Industry Applications in the Chemical Engineering Undergraduate Curriculum and K-12 Education Abstract

Rowan University, in collaboration with the National Science Foundation (NSF) funded Engineering Research Center for Structured Organic Particulate Systems (C-SOPS), is developing teaching modules and problem sets to introduce students to engineering concepts in the particle and powder technology of pharmaceutical processing and drug delivery systems. The Center is hosted by Rutgers University and also includes Purdue University, the New Jersey Institute of Technology, and the University of Puerto Rico, Mayaguez. The goal of the Center is to become a national focal point for developing structured organic particulate systems used in pharmaceuticals and their manufacturing processes. Rowan University has partnered as an outreach/education member institution to develop teaching modules for K-12 and college level students. Teaching modules for nano-particle manufacturing, V-mixer applications, and general particulate properties have been developed and implemented. In addition, problem sets illustrating drug delivery systems and pharmaceutical manufacturing concepts have been developed. These problem sets and the flexible and interactive teaching modules are excellent educational vehicles to introduce students to pharmaceutical processing, drug delivery and basic principles in particle and powder technology. These efforts will also serve to teach engineering concepts in the context of pharmaceutical industry particle and powder operations. The teaching modules and problem sets will be used in undergraduate mass and energy balances, fluid mechanics and transport courses. They will also be used in workshops for middle and high school students and teachers. The completed educational materials will be incorporated into the C-SOPS website for use by Center members and faculty at other schools. This work will serve to expand and strengthen the educational impact of the Center in the region and throughout the country.

Introduction

The NSF-sponsored Center for Structured Organic Particulate Systems (C-SOPS) is striving to become a focal point in pharmaceutical processing. The overall goals of the Engineering Research Center are coordinated through carefully planned thrust areas. The thrust areas include the major research initiatives of the Center: manufacturing science; composites structuring and characterization; and particle formation and functionalization. Three test beds based on programs developed from the thrust areas have been created at the Center. Development Program I concentrates on the continuous manufacturing of pharmaceutical tablets. Continuous tablet manufacturing processes offer significant advantages over batch processes. These advantages include an increase in tablet uniformity and stability, reduced production and labor costs and simplified scale up from experimental testing to full scale manufacturing1. Development Programs II and III focus on novel methods for drug delivery. Development Program II focuses on the stabilization of API (active pharmaceutical ingredient) nano-particles in edible substrates1, 2. The higher surface areas of nano-particles results in higher material bioavailability. Finally, Development Program III includes a drop-on-demand system to layer API’s on an edible substrate1, 2. The system could be portable and compact for use in third world

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Gephardt, Z. O., & Farrell, S., & Savelski, M., & Robert, K., & Slater, C. S., & DeDelva, V., & Glasspool, M., & Iftikhar, M., & McIver, K., & Ross, K., & Whitaker, K., & Sokal, T. (2010, June), Integration Of Particle Technology With Pharmaceutical Industry Applications In The Chemical Engineering Undergraduate Curriculum And K 12 Education Paper presented at 2010 Annual Conference & Exposition, Louisville, Kentucky. 10.18260/1-2--15885