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Interactive Web-based Virtual Environment for Learning Single-Use Biomanufacturing Technologies

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2014 ASEE Annual Conference & Exposition


Indianapolis, Indiana

Publication Date

June 15, 2014

Start Date

June 15, 2014

End Date

June 18, 2014



Conference Session

Biomedical Division Poster Session

Tagged Division


Page Count


Page Numbers

24.796.1 - 24.796.7



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Paper Authors


Yakov E. Cherner ATEL, LLC

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Dr. Yakov E. Cherner, a Founder and President of ATEL, LLC, taught science, engineering and technology disciplines to high school, college and university students. He has extensive experience in writing curricula and developing educational software and efficient instructional strategies. Dr. Cherner introduced an innovative concept of multi-layered simulation-based conceptual teaching of science and technology. This instructional approach uses real-world objects, processes and learning situations that are familiar to students as the context for virtual science, engineering and technology investigations. He also proposed and implemented the pioneering concept of integrated adjustable virtual laboratories. To facilitate these methodologies for academic education, corporate and military training, his company developed new ground-breaking e-learning solutions, as well as relevant assessment and authoring tools. Dr. Cherner holds an MS in Experimental Physics, and Ph.D. in Physics and Materials Science. He published over 90 papers in national and international journals and made dozens presentations at various national and international conferences and workshops. Dr. Cherner has served as a Principal Investigator for several government-funded educational projects.

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Bruce R. Van Dyke Quincy College

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Bruce Van Dyke received a B.S. in chemistry from the University of California, San Diego (UCSD) and his M.S. in biochemistry from Western Washington University. He spent 17 years performing biomedical research in the Biology Department at UCSD and five years in industrial research in Seattle, Washington. After leaving industry, Bruce joined the biotechnology program at Shoreline Community College in Seattle where he developed and taught courses in biotechnology. In 2006, he was invited to join Sonia Wallman and the Northeast Biomanufacturing Center and Collaborative (NBC2) in Portsmouth, New Hampshire where he spent five years teaching in the biomanufacturing program. Bruce is currently the Chair of the Biotechnology and Compliance Program at Quincy College in Quincy, MA and a consultant for NBC2.

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Interactive Web-based Virtual Environment for Learning Single-Use Biomanufacturing TechnologiesThe paper presents a highly interactive comprehensive learning environment for teaching andlearning the latest industrial scale single-used biomanufacturing production. The first simulation-based e-learning module focuses on upstream processing using completely disposable technologyand equipment. The simulations, which form the core of the module, can be run in the followingthree modes: Introduction, Practice, and Assessment.The Introduction mode enables students to explore disposable upstream processing procedures inwhich various types of bioreactors are used, as well as to get familiar with design, functions andinterconnections of major system components. Students can zoom-in on components, rotate them,and explore their parts using 3D models. The interactive workflow chart helps students to learnthe sequence of procedures and the purposes and features of each procedure.In the Practice mode students apply their acquired knowledge to assemble disposable systemsand manually conduct the processes using computer mouse and keyboard, following detailedstep-by-step instructions.In addition to simulations, the module includes links to online textbooks, presentations, technicalmanuals, Standard Operating Procedures (SOP), assessment quizzes and a variety of other onlinelearning resources that address the education and training needs of biopharmaceuticaltechnicians. All theses resources instantly available to the students provide a “just-in-time”learning experienceIn the assessment mode, performance-based and sequential self tests help students to self-controltheir knowledge and progress. Students are required to complete technological processes on theirown with minimal or no instructions and support. The program tracks the user’s actions, answersto the system-generated quizzes and records the elapsed time.Virtual activities are integrated with actual disposable systems and equipment available at thecollege biomanufacturing laboratory. Such combinations helps students better understand thepurposes of procedures they perform and enhances students’ comprehension of the underlyingchemical and biological processes.The paper will discuss integration of the e-learning environment into biomanufacturing curriculaand piloting it with Quincy College students.The virtual environment is being developed with a partial support from the Department of LaborTAACCCT Grant.Screenshot of the Virtual Single-Use Biomanufacturing Environment. The module presented inthe figure allows students to assemble a disposable bioreactor (bottom right), explore allprocedures and steps of the upstream process workflow (bottom middle) and operate the reactorusing interface controls and meters. A video clip illustrated a current step of the technologicalcycle can be played in a separate panel (middle right). Manipulating virtual 3D models of vessels,tools and materials, the student can perform actual workplace tasks online (bottom right).

Cherner, Y. E., & Van Dyke, B. R. (2014, June), Interactive Web-based Virtual Environment for Learning Single-Use Biomanufacturing Technologies Paper presented at 2014 ASEE Annual Conference & Exposition, Indianapolis, Indiana. 10.18260/1-2--20688

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