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PhysioLAB edu™ : An Interactive, Modeling and Simulation System for Learning and Research in Biomedicine

Gilbert A. Chauvet1,2 and Pierre Chauvet3 1 IBT, Fac. Médecine, 10 rue A. Boquel, 49100 Angers, France / 2 BME, Univ. South. Calif., Los Angeles CA 90089, USA 3 / Inst. de Math. Appl., UCO, rue Rabelais, 49000 Angers; France)

Abstract: PhysioLAB edu™ is an educational and research tool that provides numerical experiments within a simulation system. It uses simulations of mathematical models to represent how real biological systems work. Using this system makes possible the integration of physiological systems. This computing system is an object-oriented program based on a unifying theoretical framework with a common formalism for phenomena at different levels of a hierarchical system. Students may interactively investigate the basic mechanisms of physiological phenomena. Faculty and engineers may use PhysioLAB edu for teaching and research (because their own models can be inserted in the time and space algorithm that allows traversing levels of organizations).

I. Aim of the physiolab edu System: Integrative Physiology

The primary aim of PhysioLAB edu is to describe the phenomena of biological systems, from elementary physiological mechanisms to global function, in such a way that: 1. A unique conceptual framework with general principles and concepts specific to biology are used, which provides: The same common bases for interpretation of biological phenomena; The same bases for, ultimately, improving biological knowledge. It will be shown that this is obtained using a specific formalism (the S-Propagator Formalism) to traverse levels of organization, and to study couplings between sub -systems in the organism.

2. The results of simulations under the usual form of mathematical curves simultaneously associated with what happens in physical reality, e.g. injection of current at a given point across the membrane simultaneously with the recorded potential curve (Fig 1).

3. The system allows analysis and understanding of the role of internal and environmental parameters on the phenomena (e.g. temperature, friction). These parameters are presented in a panel with their default values. It is possible to quantitatively observe the role of experimental conditions, i.e. the role played by controlled parameters, on the physiological process (e.g. ion species, holding potential); their values can be continuously chosen using a scrollbar and results are simultaneously presented.

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Chauvet, P., & Chauvet, G. A. (2000, June), Physio Lab Edu: An Interactive, Modeling And Simulation System For Learning And Research In Biomedicine. Paper presented at 2000 Annual Conference, St. Louis, Missouri. 10.18260/1-2--8627