Farrell, S., & Vernengo, J., & Montgomery, S. E., & Zhang, Y., & Schwalbenberg, P. J. (2012, June), An Experiment to Introduce pH-responsive Hydrogels for Controlled Drug Delivery  Paper presented at 2012 ASEE Annual Conference & Exposition, San Antonio, Texas. 10.18260/1-2--20923

\bibitem{asee_peer_20923}
  Farrell, S., \& Vernengo, J., \& Montgomery, S. E., \& Zhang, Y., \& Schwalbenberg, P. J. (2012, June), \emph{An Experiment to Introduce pH-responsive Hydrogels for Controlled Drug Delivery}
  Paper presented at 2012 ASEE Annual Conference \& Exposition, San Antonio, Texas.
  10.18260/1-2--20923

Stephanie Farrell, Jennifer Vernengo, Stephen E. Montgomery, Yang Zhang, and Peter John Schwalbenberg.  "An Experiment to Introduce pH-responsive Hydrogels for Controlled Drug Delivery".  2012 ASEE Annual Conference & Exposition, San Antonio, Texas, 2012, June.  ASEE Conferences, 2012.  https://peer.asee.org/20923 Internet.  26 Dec, 2024

\bibitem{asee_peer_20923}
  Stephanie Farrell, Jennifer Vernengo, Stephen E. Montgomery, Yang Zhang, and Peter John Schwalbenberg.
  "An Experiment to Introduce pH-responsive Hydrogels for Controlled Drug Delivery".
  \emph{2012 ASEE Annual Conference \& Exposition, San Antonio, Texas, 2012, June}.
  ASEE Conferences, 2012.
  https://peer.asee.org/20923 Internet.  26 Dec, 2024

@INPROCEEDINGS{asee_peer_20923
author = "Stephanie Farrell, Jennifer Vernengo, Stephen E. Montgomery, Yang Zhang, and Peter John Schwalbenberg"
title = "An Experiment to Introduce pH-responsive Hydrogels for Controlled Drug Delivery"
booktitle = "2012 ASEE Annual Conference \& Exposition"
year = "2012"
month = "June"
address = "San Antonio, Texas"
publisher = "ASEE Conferences"
note = {https://peer.asee.org/20923}
number = {10.18260/1-2--20923}
}

TY  - CPAPER
AB  - Proposed Abstract for the NSF Grantees Poster SessionAn Experiment to Introduce pH-responsive Hydrogels for Controlled Drug DeliveryStephanie Farrell and Jennifer VernengoDepartment of Chemical EngineeringRowan UniversityStimuli-responsive polymers are used in a variety of biomedical applications. Forexample, pH responsive hydrogels have been extensively investigated for controlled drugdelivery. By responding to the pH environment in the body, which changes depending onlocation and metabolic state, a pH-sensitive drug dosage form is able to modulate drugdelivery patterns to meet physiologic requirements and minimize side effects. This paperdescribes an experiment used to introduce freshmen engineering students to stimuli-responsive polymers for controlled release applications. Students produce a pHresponsive hydrogel using a free-radical solution polymerization. The physical andmechanical properties of the hydrogel such as swelling, density, and tensile strength aretested with and without drug loading, after exposure to different pH environments.Finally, the drug release profiles were analyzed in different pH environments. At low pH(typical stomach values of 1.2-5.0) the drug did not swell and drug was released veryslowly. At neutral pH (representative of gastric emptying), the gels swelled rapidly andreleased drug at a controlled rate. Such a system would be useful for the oral delivery ofa drug that would be damaged by the low pH environment of the stomach, such asinsulin. In addition to learning about pH-responsive drug delivery, students learnedconcepts of measurements, material properties, design of experiments, data analysis, andengineering design.
AU  - Stephanie Farrell
AU  - Jennifer Vernengo
AU  - Stephen E. Montgomery
AU  - Yang Zhang
AU  - Peter John Schwalbenberg
CY  - San Antonio, Texas
DA  - 2012/06/10
PB  - ASEE Conferences
TI  - An Experiment to Introduce pH-responsive Hydrogels for Controlled Drug Delivery
UR  - https://peer.asee.org/20923
DO  - 10.18260/1-2--20923
ER  -